Cropped, Drosophila transcription factor AP-4, controls tracheal terminal branching and cell growth
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چکیده
منابع مشابه
branchless Encodes a Drosophila FGF Homolog That Controls Tracheal Cell Migration and the Pattern of Branching
The molecular basis for patterning of complex organ structures like the lung and insect tracheal system is unknown. Here, we describe the Drosophila gene branchless (bnl) and demonstrate that it is a key determinant of the tracheal branching pattern. bnl is required for tracheal branching and is expressed dynamically in clusters of cells surrounding the developing tracheal system at each positi...
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Transcription factor AP-2 is essential for craniofacial, nervous system, and limb development in the mouse. We report here the cloning and expression pattern analysis of DAP-2, the Drosophila homolog of AP-2 family genes. DAP-2 is expressed in discrete regions of procephalic neuroectoderm, the brain, ventral nerve cord, and maxillary segment during Drosophila embryogenesis, and in the brain, op...
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Many organs including the mammalian lung and vascular system consist of branched tubular networks that transport essential gases or fluids, but the genetic programs that control the development of these complex three-dimensional structures are not well understood. The Drosophila melanogaster tracheal (respiratory) system is a network of interconnected epithelial tubes that transports oxygen and...
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We identified a Drosophila gene, pruned, that regulates formation of the terminal branches of the tracheal (respiratory) system. These branches arise by extension of long cytoplasmic processes from terminal tracheal cells towards oxygen-starved tissues, followed by formation of a lumen within the processes. The pruned gene is expressed in terminal cells throughout the period of terminal branchi...
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9 REVIEW OF LITERATURE 10 1. Signal transduction 10 1.1. Signaling during cell growth, differentiation, and apoptosis 10 1.2. Transcritional regulation of gene expression 11 2. Mitogen activated protein kinases (MAPKs) 11 2.1. ERK MAPKs 13 2.2. JNK MAPKs 15 2.3. p38 MAPKs 16 2.4. Transcriptional regulation by MAPKs 16 3. AP-1 transcription factor 17 3.1. AP-1 transcription factor family 17 3.2....
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ژورنال
عنوان ژورنال: BMC Developmental Biology
سال: 2015
ISSN: 1471-213X
DOI: 10.1186/s12861-015-0069-6